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1、南京中醫(yī)藥大學(xué)碩士學(xué)位論文涼血解毒法對(duì)實(shí)驗(yàn)性大鼠肝纖維化PDGF及ET干預(yù)作用的研究姓名:代海峰申請(qǐng)學(xué)位級(jí)別:碩士專(zhuān)業(yè):中醫(yī)內(nèi)科學(xué)(肝膽?。┲笇?dǎo)教師:薛博瑜20080501ABSTRACTColdhearteddegassingtoexperimentalratsliverfibrosisPDGFand11rn●^‘E1interventiontunctionresearchAbstractThebodyofhepaticfibrosi

2、sisachromcliverinjuryandrepairresponses,butalsotoallkindsofchromcliverdiseasecirrhosisdevelopmentoftheinevitablestageCurrentlyrecognizedprimarilyinthepathogenesisofavarietyofcytokinesintheliver(cytokine,CK)participationf

3、romextracellularmatrix(Extracelluarmatrix,ECM)synthesisanddegradationofbalance,thatis,ofmorethandegradation,resultinginexcessivedepositionbytheECMHasbeenconfirmedthathepaticstellatecells(hepaticstellatecell,HSC)isthemajo

4、rECMproducelivercells,liverfibrosisHSCactivationisthecentrallinkVariousfactorSleadtoliverdamageliverinjury,andthencauselivercellnecrosisandinflammatorystimulation,avarietyofrelatedcellactivationCKHSC,agreatnumberofECMRec

5、entstudiesshowthattheECMcytokines,particularlycollagenproteinmetabolism,hasanimportantrole,andinmanycytokines,PDGFontheroleofliverfibrosisparticularconcernHasnowbeenconfirmedthattheliverfiberoftheoccurrenceanddevelopment

6、,andPDGFreceptorexpressionwassignificantlyhigherthanthatofnormaltissueitsactivity、析tllthedegreeofliverfibrosisandaddincreasedespeciallyintheexpressionofHSCanddegreeofliverfibrosisWassignificantlycorrelatedThismsearchtake

7、theChinesemedicinetheoryastheinstruction,throughtheclinicalreviewandtheexperimentalstudydiscussestheliverfibrosisthecauseofdiseasepathogenesis,thepathologytoevolve,totreattheFrancesidemedicineandthecurativeeffectmechanis

8、mThoughtthatthehepatitisliverfibrosisthecauseofdiseaseismainlypoisonousfortheexternaldiseasefactorshotanddampepidemicdisease,internalinjurydietorsentimentwillbeingoutofbalance;Thebasicpathogenesisfortheliverspleenkidneyd

9、amage,thevitalitytiesmutually;Thepathologyfactorhas,theheat,thepoison,thestasiswetandSOon;Andthestasishotwrestlesforitspathogenesiskeythetreatmentisdividedtheinitialperiodcoldhearteddisintoxicating,theclarificationishota

10、nddamp;Laterperiodadjuststhelivertotransportthespleenstraightensupremovingextravastedblood;ThetreatmentusesthemedicinehepatitisCpelletaftertheclinicalmanyyearapplicationobservation,thecurativeeffectisratheraccurateThisre

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