不對(duì)稱1,5-二芳基-1,4-戊二烯-3-酮類化合物的合成及生物活性研究.pdf

1、貴 州 大 學(xué)2009 2009 2009 2009 屆碩士研究生學(xué)位論文不對(duì)稱 1,5-二芳基-1,4-戊二烯-3-酮類化合物的合成及生物活性研究學(xué)科專業(yè)： 農(nóng) 藥 學(xué)研究方向： 新農(nóng)藥與新藥物設(shè)計(jì)和合成導(dǎo) 師： 胡 德 禹 ( 研 究 員)研 究 生： 于 大 偉中國·貴州·貴陽2009 年 5 月分 類 號(hào) ： O 6 2 3 . 5 2 2論文編號(hào)： 2006140996密 級(jí)：3.3 3.3 3.3 3.3

2、 目標(biāo)化合物的合成 目標(biāo)化合物的合成·································

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4、183;·············273.3.1 不對(duì)稱 1,5-二取代芳基-1,4-戊二烯-3-酮類化合物(I I I IA A A A)的合成..................................... 273.3.2 不對(duì)稱 1,5-二取代芳基-1,4-戊二烯-3-酮類化合物(I I I

5、IB B B B)的合成......................................333.3.3 乙基苯基碳酸酯類化合物(II II II II)的合成..............................................................................343. 3. 3. 3.4 4 4 4 目標(biāo)化合物的生物活性測試方法 目標(biāo)化合物的生物活性測試方法·&

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7、;····························363.4.1 目標(biāo)化合物抑菌活性測試方法..............................

8、..........................................................363.4.2 目標(biāo)化合物體外抗腫瘤活性測試方法.............................................................................36第四章 結(jié)果與討論 結(jié)果與討論·······&#

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11、3;··············384.1 4.1 4.1 4.1 目標(biāo)化合物合成方法研究 目標(biāo)化合物合成方法研究···············

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13、#183;······················384.1.1 目標(biāo)化合物 I I I I 的合成方法討論......................................................

14、.................................. 384.1.2 目標(biāo)化合物 II II II II 的合成方法討論.......................................................................................394.2 4.2 4.2 4.2 目標(biāo)化合物的波譜解析 目標(biāo)化合物的波譜解析····&#

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17、3;404.2.1 目標(biāo)化合物 I I I I 的譜圖解析................................................................................................ 404.2.2 目標(biāo)化合物 II II II II 的譜圖解析...............................................................

18、................................414.3 4.3 4.3 4.3 目標(biāo)化合物的生物活性測定 目標(biāo)化合物的生物活性測定························&

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20、;···········424.3.1 目標(biāo)化合物抑菌活性測試結(jié)果........................................................................................424.3.2 目標(biāo)化合物體外抗腫瘤活性測試結(jié)果....................

21、.........................................................43第五章 結(jié)論及展望 結(jié)論及展望························&#

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29、································455.3 5.3 5.3 5.3 不足與 不足與展望

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35、#183;························· 46參考文獻(xiàn) 參考文獻(xiàn)·········

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