MMP-,-9-、TIMP-,-1-的表達(dá)及微血管密度與乳腺癌生物學(xué)特性的相關(guān)性.pdf

1、蘇州大學(xué)碩士學(xué)位論文MMP、TIMP的表達(dá)及微血管密度與乳腺癌生物學(xué)特性的相關(guān)性姓名：嚴(yán)志新申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：普外指導(dǎo)教師：郭鐘行鄒士林2001.10.1▲墜堅(jiān)!!：!!堅(jiān)曼!箜耋鯊墨塑坐笪童墮蘭塾璺墮生塑堂塹堡塑塑莖絲——————————————!!蘭一AbrstractObjectiveToinvestigatecorrelationsbetweenexpressionofMMPu、TIMP1andintratumormicr

2、ovesseldensityandbiologicalcharacteristicsinhumanbreastcancerMethodsIntratumormicrovesseldensit37(MVD)andmeexpressionofMMP9andTIMPIinparafin—embeddedbreastcancinomaspecimensfrom48patientswithprimaryinvasix，ebreastcancerw

3、hohadundergoneradicalmastectomyormodifiedradicalmastectomyfromJanuaryof1990toDcecemberof1996weredetectedbythestandardstreptavidinbiotinperoxidesmethod，andtheircorrelationstoclinicopathologicfeatureswereanalyzedRusltsAmon

4、g48casethepositiveexpressionrateofMMP9andTIMP1were417％and292％respectivelyThemeanMVDofallpatientswas25391MMPⅢexpressionwerehigherinpatientswithaxillarylymphnodemetastasisthaninthosewithoutmetasttasis(p005)，andMMP9expressi

5、onwe11ehigherinpatientswithlowerhistologicalgradesthaninthosewithhigherhistologicalgrades(pO05)，andMMP9expressionwerehigherinpatientswithdistantmetastasisthaninthosewithoutdistantmetastasis(p005)，andpatientswithhigherexp

6、ressionofMMP9hadaworseprognosisthanthosewithlowerexpression(p005)TIMPjexpressionwerehigherinpatientswithlowerhistologicalgradesthaninthosewithhirgherhistologicalgrades(p005)，andTIMP1expressionswerehiIgherinpatientswithax

7、illarylymphnodemetastsisthaninthosewithoutmetastsis(p005)，andTIMPIexpressionwerehigherinpatientswithdistantmetastasisthaninthosewithoutdistantmetastasis(P005)，andpatientswithhigherexerpressionofTIMPIhadaworseprognosistha